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Test Tube Failure

Test Tube Failure

It is not always possible to achieve successful results in IVF trials. However, a young couple should generally become pregnant in 2-3 trials.Anadolu Medical Center Women's Health Department Coordinator Dr. Contact Aydin directly Ta In the group over the age of 40, the number of trials may increase because failure rates normally increase. Erek test tube applications.

Should a retry be performed after failed IVF pregnancies?

It is not always possible to achieve successful results in IVF trials. The most important factor to be considered when evaluating the success rates in IVF is the age of the woman. Failure rates increase with age. The most important reason for this is the fact that the genetic disorders in the eggs are more common with the progression of age. However, even in young couples, although everything seems normal, pregnancy may not occur even with IVF treatment. At this point, although medicine can not explain everything, 'fate, luck, fate,' such suggestions can be brought, although the proposal of medical scientists is to retry. The point to be considered here is to take lessons from the first attempt and to examine the answer of that couple in the first attempt and try to make them more successful in the second attempt.

What is the percentage of in vitro fertilization failure?

The most important factor in IVF success rates is the age of the woman. Generally, in good IVF programs, if the woman is younger than 35, the success rate for each trial is around 60%, even if everything goes perfectly. Pregnancy rates decrease to 45% in the 35-37 age group. In the 38-40 age group, this rate is around 30%. This rate decreases to 20% in the 40-42 age group and reaches even lower numbers above 42. Women who are 45 years or older have a chance of getting pregnant under 5% in each trial. Beyond the woman's age, many other factors influence success. The first of these is whether the male's sperm is normal, whether the female's ovulation functions are normal, whether there is any problem in the uterus, that is, the uterus.

How many attempts should a family make at most?

One the family how many attempts he will make at most depends on the financial and moral strength of that family. However, a young couple should generally become pregnant in 2-3 trials. Therefore, they should not despair once with unsuccessful results. In the group over 40 years of age, the number of trials may increase as failure rates increase normally. However, for example, a couple who failed in 6 attempts had little chance of succeeding in the 7th attempt. To give you a number, more than 6 attempts are generally not recommended. This advice is due to the fact that the likelihood of success is now much less than the fear of damaging the body. As with every subject, there are exceptions; occasionally we read news in the newspapers, for example in the 13th attempt after 12 failed attempts pregnant The stories of the remaining couples. The important thing to note here is that these are rare events that will become newspaper news.

Does each trial affect the chances of success of the next one?

I present the graph from a scientific article published in 2005 above. In this study of 750 couples in Europe, the numbers on the left of the graph show the live birth rates in each IVF trial regardless of age. The numbers below show how many attempts were made to couples who could not become pregnant. This research gives us the following information: The expected success rate of a couple who failed in the first attempt was 70% of the first. In subsequent trials, the chances of success are consistently half that of the previous one. The important thing here is of course not to blindly attempt a test tube baby without much research. After each trial, the causes of failure should be investigated in detail and appropriate treatments should be performed. There may be many problems that may have been overlooked initially.

How are the mental state of couples who fail in succession affected?

Every IVF trial affects a pair from every angle. The most important of these is the mental state. Both during IVF treatment doctor and the treated couple naturally begins and maintains treatment in great hopes. At every stage of the treatment, this hope increases. Failure of the result usually results in a major mental breakdown. In addition, women are the most affected mentally due to hormone ups and downs. In addition to mental status, it is not possible for couples to be affected both physically and financially.

Can the number of in vitro fertilization trials be limited by law? are there countries that do this?

The number of in vitro fertilization trials can only be limited in countries with universal health insurance and where in vitro fertilization costs are covered by the state. For example, in the Scandinavian countries, IVF treatment is fully covered by the state, but is limited to 3 trials and has an age limit. In Australia, it was limited to 6 trials. There is no limit in Israel. In no country is a trial of double in vitro fertilization as long as it pays for its own treatment.

How long after an unsuccessful attempt can someone else be tried?

After an unsuccessful IVF attempt, a break of at least one month is required. It is not only the physical reasons that matter here. Spiritually, especially women need a time to recover. In young couples it may be more appropriate to increase the interval to a few months. In the age group above 40 we recommend not to wait too long as opening the gap too much may decrease the success rates depending on age.

Does taking hormones for each trial adversely affect a woman's health?

Every IVF trial has certain risks. These risks include hyperstimulation, overexcitation of the ovaries, and bleeding or infection during egg collection. I would like to add to these risks the risk of multiple pregnancy because I believe this is a major complication in the long run. Estrogen hormone secretion increases with stimulation of the ovaries during tube baby therapy. This has effects such as water retention in the body, bloating in the breasts and abdomen, and spiritual tenderness. However, these effects are temporary and disappear at the end of treatment. In terms of health, these treatments do not have long-term adverse effects.

You fail couples 'do not worry again try' you say?

Of course, morale support is needed for the failed couples. Many couples consider themselves to be a deficiency, an inadequacy, and are greatly influenced by the spiritual aspect. So don't worry, it may be appropriate to give moral support to try again. However, the reasons of failure as a physician should be examined and treated to the finest details. This is the best way to increase the chances of success in the next attempt.

What do you do if pregnancy does not occur despite IVF treatment for no reason?

'There is no reason,' in fact, there is no reason we can understand. There is certainly a reason for not having a pregnancy, but medical science is far from understanding everything at the moment. Some basic tests are performed when starting a pair of IVF trials. In general, however, it is not examined to the finest details. This is due to the fact that, on many occasions, some tests are quite expensive and the likelihood of a positive (ie problematic) result is very low. Such tests can only be performed after unsuccessful attempts. As an example, I want to give, adenomyosis, cervical wall thickening and painful menstruation in a disease manifested by a test tube in vitro 'for no reason' can result in failure. The diagnosis of this disease is best made by MR (magnetic resonance). Now, do we have to do an MRI for every IVF? The answer is, of course, no. If you do this test for 100 people who are both expensive and ordinary, only 1-2 people will be positive. Therefore, we should investigate such uncommon problems only after unsuccessful trials. However, it should not avoid such tests if necessary. After unsuccessful attempts, the uterus must be reevaluated. In addition, genetic research can be performed in both spouses and embryos. A general health assessment is also required. In this way, hidden sugar, hidden thyroid disorders or other hormone disorders can be discovered and treated.

How many attempts should a family make if it is constantly aborted after the trials?

The causes of miscarriages should be investigated first. These may be due to genetic problems or disorders of the immune system. After the second abortion, both the uterus, the immune system and genetic causes must be examined. Abortions due to advanced female age are usually due to chromosomal abnormalities in embryos. These can be significantly reduced by the 'preimplantation genetic diagnosis' method in the next IVF trial.

Does the IVF Center and the doctor have to change in every trial, is there any benefit or harm?

It is not helpful to change the IVF center and the doctor in each trial. Even if each attempt fails, it sheds light on the next one, so it may be more beneficial to make a 2nd or 3rd experiment in the same center. However, opinions can be obtained from the centers or doctors who have proven themselves. On the other hand, usually after the third unsuccessful attempt, both the physician and the treated couple begin psychological fatigue and beating. In this case, experimenting in another center may be beneficial in terms of giving new hope.

How much does the next cost to the family after unsuccessful IVF trials?

In general, the cost to the family after unsuccessful IVF attempts does not change much. Some centers offer special prices in double or triple trial packages. Especially in case of additional tests to be carried out following unsuccessful attempts to increase the financial burden on the family, in my opinion it is materially and morally useful to apply some discounts to families in the 2nd or 3rd trials.


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